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Immunology Services:
Arrayed B-Cell CRISPR Screening:
It is a CRISPR-mediated gene knockout screening service in stimulated B cells. We provide a one-stop shop for complex assays in the cellular microenvironment related to gene editing. Understand the role of B cells or regulatory B cells in the regulation of immune responses, tumor shrinkage effects, or autoimmune diseases.
- Identify genes that affect B cell function by knockout.
- By knocking out genes in B cells, it identifies genes that affect the function of other immune cells.
Service Details
- Gene editing of stimulated human B cells
- Chemically synthesized crRNA: Arrayed screening with tracrRNA hybrid guide RNA
- Standard screening of 50 genes per donor, or custom screening
- Co-culture options with edited cells and other immune cells
- Data delivery time: 14-18 weeks
How can Horizon's MLR assays advance research in the development pipeline?
- 384-well assays: large-scale screening with automated, robust, and reproducible high-throughput assays
- Single agent or drug combination: Flexible assay design that can be easily customized to fit your project
- Multiple allogeneic donors: Highly enriched primary T cells and monocyte-derived dendritic cells from multiple donors are used to address donor-to-donor variability
- Multiple endpoints: Surface markers, cytokines, cell proliferation, and more provide a clear understanding of the immunomodulatory profile of the development pipeline.
- More than 10 years of combination screening experience: analysis and interpretation of expert data using proprietary Chalice Analyzer software
